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KMID : 1188320150090040494
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Gut and Liver
2015 Volume.9 No. 4 p.494 ~ p.501
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Sodium Picosulfate with Magnesium Citrate (SPMC) Plus Laxative Is a Good Alternative to Conventional Large Volume Polyethylene Glycol in Bowel Preparation: A Multicenter Randomized Single-Blinded Trial
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Kim Hyun-Gun
Huh Kyu-Chan
Koo Hoon-Sup
Kim Seong-Eun
Kim Jin-Oh
Kim Tae-Il
Kim Hyun-Soo
Myung Seung-Jae
Park Dong-Il
Shin Jeong-Eun
Yang Dong-Hoon
Lee Suck-Ho
Lee Ji-Sung
Lee Chang-Kyun
Chang Dong-Kyung
Joo Young-Eun
Cha Jae-Myung
Hong Sung-Pil
Kim Hyo-Jong
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Abstract
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Background/Aims
We investigated whether sodium picosulfate with magnesium citrate (SPMC) plus bisacodyl compares favorably with conventional polyethylene glycol (PEG) with respect to bowel cleansing adequacy, compliance, and safety.
Methods
We performed a multicenter, prospective, single-blinded study in outpatients undergoing daytime colonoscopies. Patients were randomized into a split preparation SPMC/bisacodyl group and a conventional split PEG group. We compared preparation adequacy using the Boston bowel preparation scale (BBPS), ease of use using a modified Likert scale (LS), compliance/satisfaction level using a visual analogue scale (VAS), and safety by monitoring adverse events during the colonoscopy between the two groups.
Results
A total of 365 patients were evaluated by intention to treat (ITT) analysis, and 319 were evaluated by per protocol (PP) population analysis (153 for SPMC/bisacodyl, 166 for PEG). The mean total BBPS score was not different between the two groups in both the ITT and PP analyses (p>0.05). The mean VAS score for satisfaction and LS score for the ease of use were higher in the SPMC/bisacodyl group (p<0.001). The adverse event rate was lower in the SPMC/bisacodyl group than in the PEG group (p<0.05).
Conclusions
The SPMC/bisacodyl treatment was comparable to conventional PEG with respect to bowel preparation adequacy and superior with respect to compliance, satisfaction, and safety.
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KEYWORD
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Colonoscopy, Bowel preparation, Sodium picosulfate with magnesium citrate, Polyethylene glycols
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